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Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 610-617 doi: 10.1007/s11684-021-0827-8

Abstract: However, the safety and efficacy of bevacizumab for elderly patients with advanced NSCLC require furtherWith increased toxicities, the addition of bevacizumab to PP does not improve the overall survival of elderly

Keywords： bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

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Effective interventions on health effects of Chinese rural elderly under heat exposure

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 5, doi: 10.1007/s11783-022-1545-4

Abstract:

● Education and subsidy were effective interventions during short-term heat exposure.

Keywords： High temperature     Health effect     Comprehensive evaluation     Intervention     Rural elderly    

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Construction Path of Smart Health Care Platform for the Elderly in China

Hou Hanpo, Wei He, Wang Yingchao, Yu Jin, Qiu Guixing

Strategic Study of CAE 2022, Volume 24, Issue 2,   Pages 170-178 doi: 10.15302/J-SSCAE-2022.02.023

Abstract:

China has a large elderly population and its aging speed is acceleratingTo address this, it is necessary to establish a smart health care platform for the elderly in China usingthe construction background, concept, and development status of smart health care platforms for the elderlyto strengthen information support; and geographical advantages need to be maximized to promote local elderlyachievements, improve the health assessment system for guaranteeing the physical and mental health of the elderly

Keywords： Ageing     Healthy China     home-based community care for the elderly     smart health care for the elderly     ervice for the aged     health care platform for the elderly    

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A 7-year follow-up study of the features and transformations of elderly male patients with OGTT-1h hyperglycemia

TIAN Hui, LI Chunlin, ZHONG Wenwen, PAN Changyu, LU Juming, CAO Xiutang

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 396-399 doi: 10.1007/s11684-008-0076-0

Abstract: The aim of this paper is to investigate the clinical features and transformation of elderly male patientsSeven years of follow-up visits were performed on 189 elderly male outpatients with OGTT-1h HG and data

Keywords： special attention     prevalence     unchanged     dyslipidemia     elderly    

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The early percutaneous coronary intervention in elderly patients with acute coronary syndrome

HUANG Xiong, CAO Xuebin, ZHANG Gang

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 15-18 doi: 10.1007/s11684-008-0004-3

Abstract: It is challenging to undo early percutaneous intervention (PCI) in the elderly with acute coronary syndromepercutaneous coronary intervention and were followed up for 6–12 months by telephone or in the out-patientIt was shown that early PCI might be an effective and safe method to treat elderly patients with ACS.

Keywords： door-to-balloon     percutaneous intervention     coronary syndrome     angioplasty     successful    

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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 284-286 doi: 10.1007/s11684-017-0514-y

Abstract: In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who

Keywords： arsenic trioxide     APL     rhabdomyolysis    

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: Patient-derived xenograft (PDX) models generated from human tumor samples that can retain the histologicalthe translational value of this well-annotated PDX panel in the development of co-clinical trials for patient

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral    

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Association between history of abortion and metabolic syndrome in middle-aged and elderly Chinese women

Baihui Xu, Jie Zhang, Yu Xu, Jieli Lu, Min Xu, Yuhong Chen, Yufang Bi, Guang Ning

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 132-137 doi: 10.1007/s11684-013-0250-x

Abstract: investigate the association between history of abortion and metabolic syndrome (MetS) in middle-aged and elderly

Keywords： induced abortion     spontaneous abortion     metabolic syndrome    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 506-509 doi: 10.1007/s11684-013-0294-y

Abstract:

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in

Keywords： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: To identify the potential pathogenic mutations in a Chinese patient with CF, we conducted Sanger sequencingon the genomic DNA of the patient and his parents and detected all 27 coding exons of CFTR andThe patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cisOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits the activation of immune cells through the interaction with its ligand CD24 on tumor cells. Here, by analyzing public databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10 was altered in 18 types of cancers and was associated with the clinical outcomes of 11 cancer types. In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRC) and was inversely associated with the prognosis of the patients. In 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patients compared with that in their counterpart normal kidney tissues. Moreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse prognosis. Silencing of CD24 in KIRC cells significantly increased the number of Siglec10-expressing macrophages phagocytosing KIRC cells. In addition, luciferase activity assays suggested that Siglec10 was a potential target of the transcription factors c-FOS and GATA1, which were identified by data mining. These results demonstrate that Siglec10 may have important oncogenic functions in KIRC, and represents a novel target for the development of immunotherapies.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

Hujie Song, Xiao Chen, Yalan Yu, Ling Zhang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 334-339 doi: 10.1007/s11684-017-0539-2

Abstract: Our patient is a male and 5 years and 3 months of age.

Keywords： PVS     stubborn disease     Xingnao Kaiqiao     Angong Niuhuang Wan     TCM     acupuncture    

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Ventricular tachycardia in a disseminated MDR-TB patient: a case report and brief review of literature

Hui Li,Ran Li,Jiuxin Qu,Xiaomin Yu,Zhixin Cao,Yingmei Liu,Bin Cao

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 259-263 doi: 10.1007/s11684-014-0321-7

Abstract:

Although significant breakthroughs have been achieved in tuberculosis management, we still encounter numerous difficulties in diagnosis and treatment of the disease. Additionally, a new challenge, multidrug-resistant tuberculosis (MDR-TB) with unspecific clinical presentation, often results in delayed diagnosis. In this paper, we reported a case of disseminated tuberculosis with rare presentation of ventricular fibrillation, which proved resistant to both isoniazid and rifampicin. A review of literature showed that ventricular fibrillation or tachycardia in tuberculosis patients with pericarditis or myocarditis has been sporadically reported in the past, but none has been conducted involving patients with MDR-TB infections.

Keywords： tuberculosis     MDR-TB     ventricular tachycardia    

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Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 250-253 doi: 10.1007/s11684-014-0333-3

Abstract:

The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively.The patient has suffered from hepatitis B for 30 years.The patient also presented hepatocellular carcinoma.The patient recovered uneventfully and was discharged after surgery.

Keywords： acute-on-chronic liver failure     submassive necrosis     viral hepatitis B     esophageal variceal bleeding     liver transplantation    

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Role of stair-climbing test in predicting postoperative cardiopulmonary complications in elderly patients

Pei-Tu REN BM, Bao-Chun LU MM, Zhi-Liang CHEN MM, Hong FU MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 77-81 doi: 10.1007/s11684-010-0005-x

Abstract: stair-climbing test is an effective and simple method for predicting cardiopulmonary complications in elderly

Keywords： biliary disease     cardiopulmonary complication     stair-climbing test    

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Title Author Date Type Operation

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous

Journal Article

Effective interventions on health effects of Chinese rural elderly under heat exposure

Journal Article

Construction Path of Smart Health Care Platform for the Elderly in China

Hou Hanpo, Wei He, Wang Yingchao, Yu Jin, Qiu Guixing

Journal Article

A 7-year follow-up study of the features and transformations of elderly male patients with OGTT-1h hyperglycemia

TIAN Hui, LI Chunlin, ZHONG Wenwen, PAN Changyu, LU Juming, CAO Xiutang

Journal Article

The early percutaneous coronary intervention in elderly patients with acute coronary syndrome

HUANG Xiong, CAO Xuebin, ZHANG Gang

Journal Article

Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Journal Article

Association between history of abortion and metabolic syndrome in middle-aged and elderly Chinese women

Baihui Xu, Jie Zhang, Yu Xu, Jieli Lu, Min Xu, Yuhong Chen, Yufang Bi, Guang Ning

Journal Article

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

Hujie Song, Xiao Chen, Yalan Yu, Ling Zhang

Journal Article

Ventricular tachycardia in a disseminated MDR-TB patient: a case report and brief review of literature

Hui Li,Ran Li,Jiuxin Qu,Xiaomin Yu,Zhixin Cao,Yingmei Liu,Bin Cao

Journal Article

Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Journal Article

Role of stair-climbing test in predicting postoperative cardiopulmonary complications in elderly patients

Pei-Tu REN BM, Bao-Chun LU MM, Zhi-Liang CHEN MM, Hong FU MM,

Journal Article